Phosphorylation-dependent regulation of the guanylyl cyclase-linked natriuretic peptide receptors

Regine Potthast, Lincoln R. Potter

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Natriuretic peptides are a family of hormones/paracrine factors that regulate blood pressure, cardiovascular homeostasis and bone growth. The mammalian family consists of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). A family of three cell surface receptors mediates their physiologic effects. Two are receptor guanylyl cyclases known as NPR-A/GC-A and NPR-B/GC-B. Peptide binding to these enzymes stimulates the synthesis of the intracellular second messenger, cGMP, whereas a third receptor, NPR-C, lacks enzymatic activity and functions primarily as a clearance receptor. Here, we provide a brief review of how various desensitizing agents and/or conditions inhibit NPR-A and NPR-B by decreasing their phosphorylation state.

Original languageEnglish (US)
Pages (from-to)1001-1008
Number of pages8
Issue number6 SPEC. ISS.
StatePublished - Jun 2005

Bibliographical note

Funding Information:
The work was supported by National Institutes of Health Grant R01HL66397 and American Heart Association Scientist Development Award 0130398.


  • Desensitization
  • Heart failure
  • Phosphorylation
  • Vasorelaxation
  • cGMP


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