Phosphorylation-dependent regulation of the guanylyl cyclase-linked natriuretic peptide receptors

Regine Potthast, Lincoln R. Potter

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Natriuretic peptides are a family of hormones/paracrine factors that regulate blood pressure, cardiovascular homeostasis and bone growth. The mammalian family consists of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). A family of three cell surface receptors mediates their physiologic effects. Two are receptor guanylyl cyclases known as NPR-A/GC-A and NPR-B/GC-B. Peptide binding to these enzymes stimulates the synthesis of the intracellular second messenger, cGMP, whereas a third receptor, NPR-C, lacks enzymatic activity and functions primarily as a clearance receptor. Here, we provide a brief review of how various desensitizing agents and/or conditions inhibit NPR-A and NPR-B by decreasing their phosphorylation state.

Original languageEnglish (US)
Pages (from-to)1001-1008
Number of pages8
JournalPeptides
Volume26
Issue number6 SPEC. ISS.
DOIs
StatePublished - Jun 2005

Fingerprint

Guanylate Cyclase-Coupled Receptors
C-Type Natriuretic Peptide
Natriuretic Peptides
Phosphorylation
Peptide Receptors
Guanylate Cyclase
Brain Natriuretic Peptide
Bone Development
Blood pressure
Cell Surface Receptors
Atrial Natriuretic Factor
Second Messenger Systems
Bone
Homeostasis
Hormones
Blood Pressure
Enzymes
polypeptide C
peptide B

Keywords

  • Desensitization
  • Heart failure
  • Phosphorylation
  • Vasorelaxation
  • cGMP

Cite this

Phosphorylation-dependent regulation of the guanylyl cyclase-linked natriuretic peptide receptors. / Potthast, Regine; Potter, Lincoln R.

In: Peptides, Vol. 26, No. 6 SPEC. ISS., 06.2005, p. 1001-1008.

Research output: Contribution to journalArticle

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