Phosphorylation and nuclear translocation of serine 722 and serine 910 of focal adhesion kinase in hypertrophic cardiac myocytes of left ventricle of spontaneously hypertensive rats

Ling Zhong, Xian Ping Yi, Zhan Yu Li, Faqian Li

Research output: Contribution to journalArticlepeer-review

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Abstract

Objective: To investigate the role of focal adhesion kinase (FAK) in cardiac hypertrophy induced by hypertension. Methods: Using immunofluorescent labeling, confocal microscopy and Western blot, the expression and subcellular location of FAK-pSer722 and FAK-pSer910 were determined in cardiac myocytes of the left ventricles from 2, 6, 12, and 18 month-old spontaneously hypertensive heart failure (SHHF) rats and age-matched Wistar-Kyoto (WKY) control rats, respectively. Results: There was no obvious difference in FAK-pSer722 and FAK-pSer910 expression between 2 month-old SHHF and WKY rats. In contrast with the control groups, the expression of FAK-pSer722 and FAK-pSer910 significantly increased in cardiac myocytes of the left ventricle, from 6, 12 and 18 month-old SHHF rats. Both FAK-pSer722 and FAK-pSer910 were translocated and acummulated in nuclei of cardiac myocytes from 6, 12, and 18 month-old SHHF rats. Conclusion: Phosphorylation and translocation of serine 722 and serine 910 of phosphorylated FAK play an important role in the de-compensatory cardiac hypertrophy.

Original languageEnglish (US)
Pages (from-to)328-332
Number of pages5
JournalChinese Journal of Pathology
Volume37
Issue number5
StatePublished - May 2008

Keywords

  • Focal adhesion kinase 1
  • Hypertension
  • Models, animal
  • Signaling transduction

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