PHOSPHORYLATION AND METHYLATION OF CHROMATIN PROTEINS FROM MOUSE BRAIN NUCLEI

N. M. Lee, H. H. Loh

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Abstract— Chromatin protein kinase and histone methyltransferase are present in two nuclear populations, neuronal and oligodendroglial. At least 30% of the enzymes are tightly bound to chromatin. The specific activities of both enzymes are higher in neuronal populations than in oligodendroglial. Protein kinase from these nuclear populations phosphorylates endogenous protein; however, the methyltransferase requires exogenous histone as substrate. The methyltransferase from both nuclear populations preferentially methylates lysine‐rich histone.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalJournal of Neurochemistry
Volume29
Issue number3
DOIs
StatePublished - Sep 1977

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