Keyphrases
Escherichia Coli
100%
Substrate Specificity
100%
Histidine Triad nucleotide-binding Protein 1
100%
Pronucleotides
100%
Phosphoramidate
100%
Phosphoramidase
100%
Tryptamine
54%
Nucleosides
36%
Adenosine
27%
Amines
27%
Kcat
27%
Order of Magnitude
18%
Specificity Constant
18%
OH Groups
18%
Leaving Group
18%
Nucleoside 5′-monophosphates
18%
Fluorescence Assay
9%
Sulfur
9%
Antibiotics
9%
Indole
9%
HINT1
9%
Tryptophan
9%
Kinetic Parameters
9%
Adenosine Kinase
9%
Potential Therapeutics
9%
Bioactivation
9%
Purine
9%
Hydrolysis
9%
Steady-state Kinetics
9%
Primary Amines
9%
5′-monophosphate
9%
Km Value
9%
Guanosine
9%
Binding Residues
9%
Diastereoisomers
9%
Fluorogenic
9%
Uridine
9%
Adenosine Monophosphate
9%
Thymidine
9%
Nucleoside Diphosphate Kinase
9%
Indole Derivatives
9%
Therapeutic Rationale
9%
Second-order Rate Constant
9%
Monoesters
9%
Phosphoryl
9%
Pyrimidine Analogues
9%
Am(III)
9%
Apparent Second-order Rate Constant
9%
Stereochemical Effect
9%
Monophosphorylation
9%
Hydrogen Bonds (H-bonds)
9%
Stereochemical Hypothesis
9%
Elemental Effects
9%
Biochemistry, Genetics and Molecular Biology
Binding Protein
100%
Escherichia coli
100%
Enzyme Specificity
100%
Nucleoside
100%
Histidine
100%
Tryptamine
85%
Enzyme
42%
Catalytic Efficiency
42%
Adenosine
42%
Enzymatic Hydrolysis
28%
Specificity Constant
28%
Active Site
14%
Kinetic Parameter
14%
Diastereoisomer
14%
Pyrimidine Analogue
14%
Steady State
14%
Adenosine Monophosphate
14%
Adenosine Kinase
14%
Vidarabine
14%
Tryptophan
14%
Thymidine
14%
Guanosine
14%
Uridine
14%
Pharmacology, Toxicology and Pharmaceutical Science
Substrate Specificity
100%
Escherichia coli
100%
Nucleotide Binding Protein
100%
Nucleoside
100%
Histidine
100%
Tryptamine
85%
Adenosine
42%
Bioactivation
14%
Sulfur
14%
Adenosine Phosphate
14%
Indole
14%
Cholesterol Acyltransferase
14%
Uridine
14%
Indole Derivative
14%
Tryptophan
14%
Guanosine
14%
Thymidine
14%
Purine
14%
Vidarabine
14%
Pyrimidine
14%
Adenosine Kinase
14%
Chemistry
Phosphoramidate
100%
Substrate Specificity
100%
Histidine
100%
Binding Protein
100%
Nucleoside
63%
Tryptamine
54%
Adenosine
45%
Kcat/Km
27%
Rate Constant
18%
Indole
18%
Km
18%
Enzymatic Hydrolysis
18%
Chemical Element
9%
Pharmacokinetics
9%
Hydrogen Bonding
9%
Primary Amine
9%
Phosphoryl
9%
L Isomer
9%
D-Tryptophan
9%
Purine
9%
Uridine
9%
Thymidine
9%
Guanosine
9%