Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent

Dae Hwan Suk; Dominik Rejman; Christine C. Dykstra; Radek Pohl; Krzysztof W. Pankiewicz; Steven E. Patterson

doi:10.1016/j.bmcl.2007.02.063

Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent

Dae Hwan Suk
, Dominik Rejman
, Christine C. Dykstra
, Radek Pohl
, Krzysztof W. Pankiewicz
, Steven E. Patterson

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.

Original language	English (US)
Pages (from-to)	2811-2816
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	10
DOIs	https://doi.org/10.1016/j.bmcl.2007.02.063
State	Published - May 15 2007

Keywords

Cyst wall synthase
Encystation
Giardia
Nucleotide

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10.1016/j.bmcl.2007.02.063

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title = "Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent",

abstract = "Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.",

keywords = "Cyst wall synthase, Encystation, Giardia, Nucleotide",

author = "Suk, \{Dae Hwan\} and Dominik Rejman and Dykstra, \{Christine C.\} and Radek Pohl and Pankiewicz, \{Krzysztof W.\} and Patterson, \{Steven E.\}",

year = "2007",

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doi = "10.1016/j.bmcl.2007.02.063",

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pages = "2811--2816",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Phosphonoxins

T2 - Rational design and discovery of a potent nucleotide anti-Giardia agent

AU - Suk, Dae Hwan

AU - Rejman, Dominik

AU - Dykstra, Christine C.

AU - Pohl, Radek

AU - Pankiewicz, Krzysztof W.

AU - Patterson, Steven E.

PY - 2007/5/15

Y1 - 2007/5/15

N2 - Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.

AB - Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.

KW - Cyst wall synthase

KW - Encystation

KW - Giardia

KW - Nucleotide

UR - https://www.scopus.com/pages/publications/34247498696

UR - https://www.scopus.com/pages/publications/34247498696#tab=citedBy

U2 - 10.1016/j.bmcl.2007.02.063

DO - 10.1016/j.bmcl.2007.02.063

M3 - Article

C2 - 17360182

AN - SCOPUS:34247498696

SN - 0960-894X

VL - 17

SP - 2811

EP - 2816

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 10

ER -

Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent

Abstract

Keywords

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