Phosphonoxins: Rational design and discovery of a potent nucleotide anti-Giardia agent

Dae Hwan Suk, Dominik Rejman, Christine C. Dykstra, Radek Pohl, Krzysztof W. Pankiewicz, Steven E. Patterson

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Phosphonoxins, a new class of synthetic, rationally designed anti-microbial agents, are described. From this class a sub-micromolar inhibitor of Giardia trophozoite growth has been identified.

Original languageEnglish (US)
Pages (from-to)2811-2816
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number10
DOIs
StatePublished - May 15 2007

Keywords

  • Cyst wall synthase
  • Encystation
  • Giardia
  • Nucleotide

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