Pyrrolobenzodiazepine-diethylphosphonate conjugates have been designed and synthesized that link through two different types of spacers that are simple alkane chain and also a piperazine moiety side-armed with the alkane chains. These pyrrolobenzodiazepine conjugates have exhibited remarkable DNA-binding affinity and improved solubility in water, a representative compound 7d showing promising in vitro cytotoxicity.
Bibliographical noteFunding Information:
The authors P.P.K., B.N.S., O.S and M.S.K. thank CSIR, New Delhi for the award of research fellowships. We are also thankful to the Department of Biotechnology (BT/PR/7037/Med/14/933/2006), New Delhi for financial assistance.
- DNA-binding affinity