Phospholipid autoxidation

Ned A. Porter, Carston R. Wagner

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Biological membranes are complex mixtures of lipids that aggregate to form the lipid bilayer structure. Phospholipids are key architectural components of membranes and these phospholipids are themselves highly oxidizable if they have significant polyunsaturation. Autoxidation of phospholipids proceeds to give many different peroxide products by a mechanism that is essentially the same as the mechanism for autoxidation of fatty acids or esters in the bulk phase or in inert organic solvents. This mechanism is understood reasonably well and products isolated from phospholipid autoxidation may be described based upon this general autoxidation mechanism. High pressure liquid chromatography methods for separation of complex phospholipid mixtures, including their oxidation products, have been developed and kinetic methods long used to study autoxidation in organic solvents have been translated to study autoxidation of micelles or phospholipid aggregates such as liposomes. The current status of research in this field is reviewed.

Original languageEnglish (US)
Pages (from-to)283-323
Number of pages41
JournalAdvances in Free Radical Biology and Medicine
Volume2
Issue number2
DOIs
StatePublished - 1986

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Keywords

  • Autoxidation
  • HPLC
  • hydroperoxides
  • lipid peroxidation
  • membranes
  • phospholipids

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