Phosphocitrate prevents disease progression in murine progressive ankylosis

Hollis E Krug; Maren L Mahowald; Paul B. Halverson; John D. Sallis; Herman S. Cheung

doi:10.1002/art.1780361116

Phosphocitrate prevents disease progression in murine progressive ankylosis

Hollis E Krug, Maren L Mahowald, Paul B. Halverson, John D. Sallis, Herman S. Cheung

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Objective. Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. Methods. Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle. Results. Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC‐treated and the saline‐treated mice. Conclusion. PC appears to inhibit disease progression in murine progressive ankylosis.

Original language	English (US)
Pages (from-to)	1603-1611
Number of pages	9
Journal	Arthritis & Rheumatism
Volume	36
Issue number	11
DOIs	https://doi.org/10.1002/art.1780361116
State	Published - Nov 1993

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title = "Phosphocitrate prevents disease progression in murine progressive ankylosis",

abstract = "Objective. Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. Methods. Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle. Results. Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC‐treated and the saline‐treated mice. Conclusion. PC appears to inhibit disease progression in murine progressive ankylosis.",

author = "Krug, {Hollis E} and Mahowald, {Maren L} and Halverson, {Paul B.} and Sallis, {John D.} and Cheung, {Herman S.}",

year = "1993",

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T1 - Phosphocitrate prevents disease progression in murine progressive ankylosis

AU - Krug, Hollis E

AU - Mahowald, Maren L

AU - Halverson, Paul B.

AU - Sallis, John D.

AU - Cheung, Herman S.

PY - 1993/11

Y1 - 1993/11

N2 - Objective. Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. Methods. Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle. Results. Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC‐treated and the saline‐treated mice. Conclusion. PC appears to inhibit disease progression in murine progressive ankylosis.

AB - Objective. Mice with progressive ankylosis, a spontaneous arthropathy, were treated with phosphocitrate (PC) in vivo to determine the effect of PC on disease progression. Methods. Two groups of mice with progressive ankylosis (matched for age, weight, and sex) were treated parenterally for 6 weeks with either PC or saline vehicle. Results. Clinically, histologically, and microradiographically, there were significant differences in disease progression and severity in the PC‐treated and the saline‐treated mice. Conclusion. PC appears to inhibit disease progression in murine progressive ankylosis.

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Phosphocitrate prevents disease progression in murine progressive ankylosis

Abstract

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