TY - JOUR
T1 - Phosphate-tether-mediated ring-closing metathesis for the preparation of complex 1,3-anti-diol-containing subunits
AU - Chegondi, Rambabu
AU - Maitra, Soma
AU - Markley, Jana L.
AU - Hanson, Paul R.
PY - 2013/6/17
Y1 - 2013/6/17
N2 - An array of examples of diastereoselective, phosphate-tether-mediated ring-closing metathesis reactions, which highlight the importance of product ring size and substrate stereochemical compatibility, as well as complexity, is reported. Studies focus primarily on the formation of bicyclo[n.3.1]phosphates, involving the coupling of C2-symmetric dienediol subunits with a variety of simple, as well as complex, alcohol partners. Phosphate-tether mediation: An array of examples of diastereoselective, phosphate-tether-mediated ring-closing metathesis reactions, which highlight the importance of product ring size and substrate stereochemical complexity, is reported (see scheme). Bicyclo[n.3.1]phosphates can be prepared utilizing the tripodal coupling of C2-symmetric dienediol subunits with a variety of simple, as well as complex alcohol partners.
AB - An array of examples of diastereoselective, phosphate-tether-mediated ring-closing metathesis reactions, which highlight the importance of product ring size and substrate stereochemical compatibility, as well as complexity, is reported. Studies focus primarily on the formation of bicyclo[n.3.1]phosphates, involving the coupling of C2-symmetric dienediol subunits with a variety of simple, as well as complex, alcohol partners. Phosphate-tether mediation: An array of examples of diastereoselective, phosphate-tether-mediated ring-closing metathesis reactions, which highlight the importance of product ring size and substrate stereochemical complexity, is reported (see scheme). Bicyclo[n.3.1]phosphates can be prepared utilizing the tripodal coupling of C2-symmetric dienediol subunits with a variety of simple, as well as complex alcohol partners.
KW - bicyclic phosphate
KW - diastereotopic differentiation
KW - natural products
KW - phosphate tether
KW - ring-closing metathesis
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U2 - 10.1002/chem.201300913
DO - 10.1002/chem.201300913
M3 - Article
C2 - 23712660
AN - SCOPUS:84878839481
SN - 0947-6539
VL - 19
SP - 8088
EP - 8093
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 25
ER -