Abstract
A protecting group Ph(O) for terminal ethyne was newly developed. This protecting group can be introduced readily to terminal ethyne by CuI-catalyzed phosphination and subsequent oxidation with H Ph(O)-protected ethynes remained intact in Sonogashira coupling, and their high polarity enabled easy separation of the desired coupling product from by-products. By treatment with t-BuOK, Ph(O)-protected ethynes were transformed to the corresponding terminal ethynes.
| Original language | English (US) |
|---|---|
| Article number | U04611ST |
| Pages (from-to) | 2402-2406 |
| Number of pages | 5 |
| Journal | Synlett |
| Issue number | 16 |
| DOIs | |
| State | Published - 2011 |
Keywords
- alkynes
- coupling
- phosphorylation
- protecting groups