Pheromone-inducible conjugation in Enterococcus faecalis: A model for the evolution of biological complexity?

Briana K. Kozlowicz; Martin Dworkin; Gary M Dunny

doi:10.1016/j.ijmm.2006.01.040

Pheromone-inducible conjugation in Enterococcus faecalis: A model for the evolution of biological complexity?

Briana K. Kozlowicz, Martin Dworkin, Gary M Dunny

Microbiology

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

Pheromone-inducible transfer of the plasmid pCF10 in Enterococcus faecalis is regulated using a complicated network of proteins and RNAs. The plasmid itself has been assembled from parts garnered from a variety of sources, and many aspects of the system resemble a biological kluge. Recently several new functions of various pCF10 gene products that participate in regulation of plasmid transfer have been identified. The results indicate that selective pressures controlling the evolution of the plasmid have produced a highly complex regulatory network with multiple biological functions that may serve well as a model for the evolution of biological complexity.

Original language	English (US)
Pages (from-to)	141-147
Number of pages	7
Journal	International Journal of Medical Microbiology
Volume	296
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ijmm.2006.01.040
State	Published - Apr 6 2006

Bibliographical note

Funding Information:
The research in our laboratory is supported by PHS grants GM49530 and HL51987 from the NIH, and a Grant-in-aid from the Graduate School of the University of Minnesota. B.K. Kozlowicz was supported by an NIH traineeship under T32 GM08347, and by a Dissertation fellowship from the University of Minnesota Graduate School.

Keywords

Genetic regulation
Horizontal gene transfer
Peptide signal molecule

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title = "Pheromone-inducible conjugation in Enterococcus faecalis: A model for the evolution of biological complexity?",

abstract = "Pheromone-inducible transfer of the plasmid pCF10 in Enterococcus faecalis is regulated using a complicated network of proteins and RNAs. The plasmid itself has been assembled from parts garnered from a variety of sources, and many aspects of the system resemble a biological kluge. Recently several new functions of various pCF10 gene products that participate in regulation of plasmid transfer have been identified. The results indicate that selective pressures controlling the evolution of the plasmid have produced a highly complex regulatory network with multiple biological functions that may serve well as a model for the evolution of biological complexity.",

keywords = "Genetic regulation, Horizontal gene transfer, Peptide signal molecule",

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note = "Funding Information: The research in our laboratory is supported by PHS grants GM49530 and HL51987 from the NIH, and a Grant-in-aid from the Graduate School of the University of Minnesota. B.K. Kozlowicz was supported by an NIH traineeship under T32 GM08347, and by a Dissertation fellowship from the University of Minnesota Graduate School.",

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