Phenytoin and phenobarbital concentrations in serum: A comparison of ames seralyzer with GLC, TDX, and EMIT

I. E. Leppik, K. S. Oies, M. L. Sheehan, J. K. Penry, D. R. Parker, T. K. Gallagher, G. P. Caron, W. Rosenfeld, J. J. Salmon

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

A recently developed system for measuring antiepileptic drug concentrations was evaluated for phenytoin and phenobarbital. The apoenzyme reactive immunoassay system was compared with gas-liquid chromatography, EMIT, and TDX systems. Comparisons were performed with control specimens and with sera obtained from patients at three facilities. Precision for all methods was similar, with within-run and between-run coefficients of variation generally 5%. The accuracy of all methods was acceptable, but bias was present in some. However, measurements obtained by a nontechnical person (physician) in a clinical setting were sometimes inaccurate.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalTherapeutic drug monitoring
Volume11
Issue number1
DOIs
StatePublished - Jan 1989

Keywords

  • Antiepileptic drug concentrations
  • Immunoassay
  • Phenobarbital
  • Phenytoin

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