Phenytoin and Formation of T Lymphocyte Rosettes

Barbara A. Neilan, Ilo E Leppik

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Phenytoin sodium has been associated with the formation of altered T lymphocyte rosettes in vitro. To investigate the clinical relevance of this observation, the formation of T lymphocyte rosettes in nine patients was studied before treatment with phenytoin and after therapeutic concentrations of the drug in plasma were attained. The percentage of total rosette-forming cells found before treatment was not significantly different from the percentage found 24 hours after treatment. Likewise, the percentage of active rosette-forming cells before phenytoin therapy was not significantly less than after therapy. These results suggest that in vivo treatment with phenytoin does not acutely inhibit the formation of T lymphocyte rosettes.

Original languageEnglish (US)
Pages (from-to)580-581
Number of pages2
JournalArchives of Neurology
Volume37
Issue number9
DOIs
StatePublished - Sep 1980

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