Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon system

Keyphrases

• Sleeping Beauty Transposon 100%
• Long-term Expression 100%
• Non-viral Gene Delivery 100%
• Phenotypic Adjustment 100%
• Hemophilia 66%
• Factor VIII Gene 66%
• Clinically Significant 33%
• Sleeping Beauty 33%
• Gene Therapy 33%
• Liver 33%
• Immune Response 33%
• Mouse Model 33%
• Plasmid 33%
• Neonate 33%
• Complementary DNA (cDNA) 33%
• Protein Drug 33%
• Genomic DNA (gDNA) 33%
• Gene Delivery 33%
• Neoantigen 33%
• Bleeding Disorders 33%
• Human Factor VIII 33%
• Non-viral 33%
• Linker 33%
• Polymerase Chain Reaction 33%
• Insertion Site 33%
• Secreted Proteins 33%
• Antibody Production 33%
• Transgene Integration 33%
• Plasma Factors 33%
• Transposon Insertion 33%
• Tail Vein Injection 33%
• Co-injection 33%
• Therapeutic Plasma 33%
• Naked Plasmid DNA 33%
• Facial Vein 33%
• Recombinant Factor VIII 33%
• Coagulation Factor VIII 33%
• Haemophilia A Mice 33%
• Inhibitory Antibody 33%
• Factor VIII Level 33%
• B-domain Deleted Recombinant Factor VIII 33%

Biochemistry, Genetics and Molecular Biology

• Transposable Element 100%
• Factor VIII 100%
• Nonviral Gene Delivery System 100%
• Haemophilia A 33%
• Plasmid 22%
• Mouse Model 11%
• Gene Therapy 11%
• Transgene 11%
• Coagulation Factor VIII 11%
• Gene Targeting 11%
• Immune Response 11%
• Antibody Production 11%
• Plasma Factor 11%
• Transposase 11%
• Genomics 11%
• Polymerase Chain Reaction 11%