Abstract
The majority of MRI phase imaging is based on gradient recalled echo (GRE) sequences. This work studies phase contrast behavior due to small off-resonance frequency offsets in brain using SWIFT, a FID-based sequence with nearly zero acquisition delay. 1D simulations and a phantom study were conducted to describe the behavior of phase accumulation in SWIFT. Imaging experiments of known brain phase contrast properties were conducted in a perfused rat brain comparing GRE and SWIFT. Additionally, a human brain sample was imaged. It is demonstrated how SWIFT phase is orientation dependent and correlates well with GRE, linking SWIFT phase to similar off-resonance sources as GRE. The acquisition time is shown to be analogous to TE for phase accumulation time. Using experiments with and without a magnetization transfer preparation, the likely effect of myelin water pool contribution is seen as a phase increase for all acquisition times. Due to the phase accumulation during acquisition, SWIFT phase contrast can be sensitized to small frequency differences between white and gray matter using low acquisition bandwidths.
Original language | English (US) |
---|---|
Pages (from-to) | 20-28 |
Number of pages | 9 |
Journal | Journal of Magnetic Resonance |
Volume | 252 |
DOIs | |
State | Published - Mar 2015 |
Bibliographical note
Publisher Copyright:© 2015 Elsevier Inc. All rights reserved.
Keywords
- Brain
- FID
- Gray matter
- Magnetization transfer
- Orientation
- Phase
- SWIFT
- White matter