Pharmacological profiles of β-funaltrexamine (β-FNA) and β-chlornaltrexamine (β-CNA) on the mouse vas deferens preparation

Susan J. Ward, Philip S Portoghese, A. E. Takemori

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120 Scopus citations

Abstract

The profiles of action of β-funaltrexamine (β-FNA) and β-chlornaltrexamine (β-CNA) have been assessed in the mouse vas deferens preparation. β-FNA, but not β-CNA, demonstrated a reversible agonist action that appeared to be mediated via κ-receptor interaction. β-CNA produced an irreversible antagonism of μ-, κ- and δ-mediated agonist actions, whereas β-FNA irreversibly antagonized μ-mediated agonist effects only. This selective action of β-FNA could also be seen following administration in vivo. β-CNA and particularly β-FNA should prove valuable in the elucidation of multiple opioid receptors.

Original languageEnglish (US)
Pages (from-to)377-384
Number of pages8
JournalEuropean Journal of Pharmacology
Volume80
Issue number4
DOIs
StatePublished - Jun 4 1982

Keywords

  • Mouse vas deferens
  • Multiple receptors
  • Selective antagonism
  • β-CNA
  • β-FNA

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