Pharmacological intervention in invertebrate aging

Gordon J. Lithgow, Matthew S. Gill, Anders Olsen, James N. Sampayo

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Prompted by successful genetic interventions in aging we now consider the utility of pharmacological interventions. A few clear cases of lifespan extension resulting from exposure to compounds suggest that aging can be slowed and that the pharmacology of lifespan extension is a feasible area for research. Compounds that slow aging may prompt the rational design of therapeutics against age-related diseases. Here we evaluate invertebrate models for drug discovery in aging and outline how the field may develop from these simple first steps.

Original languageEnglish (US)
Pages (from-to)213-223
Number of pages11
Issue number3
StatePublished - Sep 2005
Externally publishedYes


  • Aging
  • Anti-aging drugs
  • Antioxidant
  • Invertebrates
  • Lifespan
  • Pharmacology
  • Stress


Dive into the research topics of 'Pharmacological intervention in invertebrate aging'. Together they form a unique fingerprint.

Cite this