Abstract
Prompted by successful genetic interventions in aging we now consider the utility of pharmacological interventions. A few clear cases of lifespan extension resulting from exposure to compounds suggest that aging can be slowed and that the pharmacology of lifespan extension is a feasible area for research. Compounds that slow aging may prompt the rational design of therapeutics against age-related diseases. Here we evaluate invertebrate models for drug discovery in aging and outline how the field may develop from these simple first steps.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 213-223 |
| Number of pages | 11 |
| Journal | AGE |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2005 |
| Externally published | Yes |
Keywords
- Aging
- Anti-aging drugs
- Antioxidant
- Invertebrates
- Lifespan
- Pharmacology
- Stress