Pharmacologic modulation of acute uveitis with aminonicotinamide

George E. Marak, Theodore W. Sery, Dale Gregerson, Larry A. Donoso, Narsing A. Rao

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The hexose monophosphate shunt inhibitor 6-aminonicotinamide was observed to have an anti-inflammatory effect in the treatment of experimental uveitis. The electrons required for the reduction of molecular oxygen to superoxide radicals are generated by the pentose phosphate pathway in acute inflammatory cells. The inhibition of superoxide production is discussed as one of the potential antiphlogistic mechanisms.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalOphthalmic Research
Volume22
Issue number2
DOIs
StatePublished - 1990

Keywords

  • 6-Aminonicotinamide
  • Experimental uveitis
  • Hexose monophosphate shunt
  • Signal transduction
  • Superoxide anion
  • Toxic oxygen metabolites

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