Abstract
In conclusion, PPIs differ slightly in their PK and PD properties and in their propensity to interact with other medications. Inhibition of acid secretion is a function of proton pump inhibition, and PPIs work in a similar fashion to achieve this goal. PK/PD principles can be used to optimize PPI therapy when considering issues related to administration, such as timing of drug delivery relative to the number of active pumps and the drug's AUC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S25-S35 |
| Journal | Gastroenterology Clinics of North America |
| Volume | 32 |
| Issue number | 3 SUPPL. |
| DOIs | |
| State | Published - Sep 2003 |
Bibliographical note
Funding Information:This work was supported by Wyeth Pharmaceuticals, Philadelphia, Pennsylvania.
