TY - JOUR
T1 - Pharmacologic considerations in the treatment of repetitive or prolonged seizures
AU - Cloyd, James
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Seizure emergencies are relatively common; however, in-hospital emergency care often is delayed by a variety of factors. Home-based treatment is effective at interrupting prolonged or repetitive seizures, but this option is underused despite its wide availability. The choice of agent used to treat seizure emergencies will depend chiefly on differences among the properties of the available drugs, particularly with regard to route of administration, lipid solubility, formulation characteristics, and the relative size of the absorptive surface area. These factors also can play a part in the decision to use one route of administration over another. Intravenous administration is the fastest and most reliable method of drug delivery, but alternative methods of drug delivery include oral, intramuscular, buccal, nasal, and rectal routes.
AB - Seizure emergencies are relatively common; however, in-hospital emergency care often is delayed by a variety of factors. Home-based treatment is effective at interrupting prolonged or repetitive seizures, but this option is underused despite its wide availability. The choice of agent used to treat seizure emergencies will depend chiefly on differences among the properties of the available drugs, particularly with regard to route of administration, lipid solubility, formulation characteristics, and the relative size of the absorptive surface area. These factors also can play a part in the decision to use one route of administration over another. Intravenous administration is the fastest and most reliable method of drug delivery, but alternative methods of drug delivery include oral, intramuscular, buccal, nasal, and rectal routes.
KW - Seizures
KW - Status epilepticus
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=34250686643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250686643&partnerID=8YFLogxK
U2 - 10.1177/08830738070220050901
DO - 10.1177/08830738070220050901
M3 - Article
C2 - 17690087
AN - SCOPUS:34250686643
SN - 0883-0738
VL - 22
SP - 47S-52S
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 5 SUPPL.
ER -