Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-κB inhibitor in mice and rats by LC-MS/MS

Keyphrases

• Pharmacokinetics 100%
• Protein Binding 100%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 100%
• NF-B 100%
• Quinoxaline 100%
• Mouse Plasma 100%
• Protein Metabolism 100%
• Urea Analogues 100%
• Lung 50%
• Plasma Concentration 50%
• Feces 50%
• Kidney 50%
• Metabolism 50%
• Pancreatic Cancer 50%
• Intravenous Administration 50%
• Tissue Distribution 50%
• In Vivo Efficacy 50%
• Metabolic Profiling 50%
• Tissue Concentration 50%
• Peripheral Tissues 50%
• Concentration Ratio 50%
• Spleen 50%
• Low Bioavailability 50%
• Plasma Proteins 50%
• Rat Urine 50%
• Rat Plasma 50%
• Mouse Liver 50%
• Well-distributed 50%
• Mouse Feces 50%
• Tmax 50%
• Rat Feces 50%
• Efficacy Data 50%
• MS Method 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein Binding 100%
• Quinoxaline 100%
• Pharmacokinetics 100%
• Pancreas Cancer 50%
• Plasma Protein 50%
• Bioavailability 50%