Pharmacokinetics of ranitidine in critically ill infants

D. B. Wiest, W. O'Neal, J. R. Reigart, R. C. Brundage, P. C. Gillette, R. L. Yost

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

The pharmacokinetic parameters of ranitidine were studied following administration of a single intravenous dose in 9 critically ill infants. Ranitidine disposition was best described by a biphasic elimination curve. For 8 patients, the mean values for T( 1/2 ), apparent volume of distribution, and total clearance were 2.09 h, 1.61 l/kg, and 13.93 ml/min/kg, respectively. Based on simulated steady-state concentration profiles, a dose of 0.7 mg/kg administered intravenously every 6 h should maintain serum levels above 40 ng/ml for 4.7 h of the dosing interval with a wide degree of variability.

Original languageEnglish (US)
Pages (from-to)7-12
Number of pages6
JournalDevelopmental Pharmacology and Therapeutics
Volume12
Issue number1
StatePublished - Jan 1 1989

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