Keyphrases
Pharmacokinetics
100%
Panobinostat
100%
Species Differences
100%
Metabolic Stability
100%
Histone Deacetylase Inhibitor (HDACi)
20%
Central Nervous System
20%
Mouse Strain
20%
Plasma Instabilities
20%
Tumor
10%
Genotype
10%
Metabolism
10%
Virus Strains
10%
Brain Tumor
10%
In Vivo Pharmacokinetics
10%
Enzymatic Activity
10%
Room Temperature
10%
Human Plasma
10%
Deregulation
10%
Red Blood Cells
10%
Systemic Administration
10%
Leukemia Virus
10%
Central Nervous System Delivery
10%
Cancer Types
10%
Endogenous Substances
10%
Degradation Rate
10%
Rapid Degradation
10%
Histone Deacetylase 1 (HDAC1)
10%
Degradation in Vitro
10%
Pharmacokinetic Behavior
10%
Interstrain Differences
10%
In Vitro Metabolic Stability
10%
Fast Degradation
10%
Systemic Pharmacokinetics
10%
Small Fraction
10%
Mouse Matrices
10%
Neuroscience
Panobinostat
100%
Pharmacokinetics
100%
In Vitro
40%
Blood Plasma
40%
Central Nervous System
30%
In Vivo
20%
Histone Deacetylase Inhibitor
20%
Behavior (Neuroscience)
10%
Histone Deacetylase
10%
Enzyme Activity
10%
Endogenous Compound
10%
Virus Strain
10%
Metabolic Pathway
10%
Intracranial Tumor
10%
Pharmacology, Toxicology and Pharmaceutical Science
Panobinostat
100%
Pharmacokinetics
100%
Mouse Strain
20%
Malignant Neoplasm
20%
Histone Deacetylase Inhibitor
20%
Central Nervous System Delivery
10%
Systemic Pharmacokinetics
10%
Systemic Administration
10%
Friend Murine Leukemia Virus
10%
Virus Strain
10%
Endogenous Compound
10%
Degradation in Vitro
10%
Intracranial Tumor
10%
Neoplasm
10%
Histone Deacetylase
10%