Patients with PBC exhibited variable pharmacokinetic parameters of cyclosporine with two patterns of elimination. The pharmacokientic modeling overestimated the dose needed to achieve the desired trough blood concentrations and was not helpful in establishing daily maintenance doses. These results are similar to conclusions found by others. Frequent and continual monitoring of cyclosporine whole blood trough concentrations is needed to obtain the desired therapeutic trough levels and to avoid toxicity in PBC patients receiving cyclosporine.
|Original language||English (US)|
|Number of pages||3|
|Issue number||2 SUPPL. 2|
|State||Published - Jan 1 1988|