Pharmacokinetics of cyclosporine in patients with primary biliary cirrhosis

P. C. De Groen, D. K. McCallum, T. P. Moyer, R. H. Wiesner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Patients with PBC exhibited variable pharmacokinetic parameters of cyclosporine with two patterns of elimination. The pharmacokientic modeling overestimated the dose needed to achieve the desired trough blood concentrations and was not helpful in establishing daily maintenance doses. These results are similar to conclusions found by others. Frequent and continual monitoring of cyclosporine whole blood trough concentrations is needed to obtain the desired therapeutic trough levels and to avoid toxicity in PBC patients receiving cyclosporine.

Original languageEnglish (US)
Pages (from-to)509-511
Number of pages3
JournalTransplantation proceedings
Issue number2 SUPPL. 2
StatePublished - 1988


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