Abstract
The physiologic disposition of the narcotic analgetic, alphaprodine (1), following iv adminstration in dogs conforms to a two-compartment, open-system model. The rapid disappearance of 1 from plasma and the large volume of distribution are in keeping with its rapid onset and short duration of action. The only extractable metabolite, noralphaprodine (2), achieved maximum plasma levels within 40 min after injection and remained constant for the duration (4 hr) of the experiment. The urine was found to contain 2 and conjugated metabolites whose identity presently is not known. Evidence is presented which suggests there is rapid equilibration between brain and plasma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 706-708 |
| Number of pages | 3 |
| Journal | Journal of Medicinal Chemistry |
| Volume | 15 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 1972 |
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Pharmacokinetics, Metabolism, and Urinary Excretion of [3H]Alphaprodine in Dogsf. / Abdel-Monem, M. M.; Harris, P. A.; Portoghese, P. S.
In: Journal of Medicinal Chemistry, Vol. 15, No. 7, 01.07.1972, p. 706-708.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetics, Metabolism, and Urinary Excretion of [3H]Alphaprodine in Dogsf
AU - Abdel-Monem, M. M.
AU - Harris, P. A.
AU - Portoghese, P. S.
PY - 1972/7/1
Y1 - 1972/7/1
N2 - The physiologic disposition of the narcotic analgetic, alphaprodine (1), following iv adminstration in dogs conforms to a two-compartment, open-system model. The rapid disappearance of 1 from plasma and the large volume of distribution are in keeping with its rapid onset and short duration of action. The only extractable metabolite, noralphaprodine (2), achieved maximum plasma levels within 40 min after injection and remained constant for the duration (4 hr) of the experiment. The urine was found to contain 2 and conjugated metabolites whose identity presently is not known. Evidence is presented which suggests there is rapid equilibration between brain and plasma.
AB - The physiologic disposition of the narcotic analgetic, alphaprodine (1), following iv adminstration in dogs conforms to a two-compartment, open-system model. The rapid disappearance of 1 from plasma and the large volume of distribution are in keeping with its rapid onset and short duration of action. The only extractable metabolite, noralphaprodine (2), achieved maximum plasma levels within 40 min after injection and remained constant for the duration (4 hr) of the experiment. The urine was found to contain 2 and conjugated metabolites whose identity presently is not known. Evidence is presented which suggests there is rapid equilibration between brain and plasma.
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UR - http://www.scopus.com/inward/citedby.url?scp=0015373659&partnerID=8YFLogxK
U2 - 10.1021/jm00277a003
DO - 10.1021/jm00277a003
M3 - Article
C2 - 5043867
AN - SCOPUS:0015373659
VL - 15
SP - 706
EP - 708
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
SN - 0022-2623
IS - 7
ER -