Pharmacokinetics and toxicity of high doses of antibody Fab fragments in rats

Keyphrases

• Pharmacokinetics 100%
• High Dose 100%
• Antibody Fab Fragment 100%
• Fab Fragment 60%
• Drug Toxicity 40%
• Antibody Fragment 40%
• Therapeutic Approaches 20%
• Blood Pressure 20%
• Baboon 20%
• Heart Rate 20%
• Specific Antibodies 20%
• Drug Interactions 20%
• Dose Effect 20%
• Self-limiting 20%
• Pharmacokinetic Parameters 20%
• Urinary Excretion 20%
• Digoxin 20%
• Urinary Protein Excretion 20%
• Human IgG 20%
• IgG-Fab 20%
• Steady-state Volume of Distribution 20%
• Serum Creatinine Concentration 20%
• Respiratory Illness 20%
• Systemic Clearance 20%
• Organ Histology 20%
• Intercurrent Infection 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Immunoglobulin F(ab) Fragment 100%
• Pharmacokinetics 100%
• Drug Toxicity 40%
• Pharmacokinetic Parameter 20%
• Infection 20%
• Respiratory Tract Disease 20%
• Creatinine 20%
• Volume of Distribution 20%
• Digoxin 20%
• Drug Interaction 20%