Pharmacokinetics and safety of a phenytoin prodrug given IV or IM in patients

I. E. Leppik; B. A. Boucher; B. J. Wilder; V. S. Murthy; C. Watridge; N. M. Graves; R. J. Rangel; C. A. Rask; P. Turlapaty

Pharmacokinetics and safety of a phenytoin prodrug given IV or IM in patients

I. E. Leppik, B. A. Boucher, B. J. Wilder, V. S. Murthy, C. Watridge, N. M. Graves, R. J. Rangel, C. A. Rask, P. Turlapaty

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phosphatases. In this study, 43 patients received ACC-9653 IV or IM. Side effects were transient and minor. The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively. Peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration.

Original language	English (US)
Pages (from-to)	456-460
Number of pages	5
Journal	Neurology
Volume	40
Issue number	3
State	Published - Mar 1990

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title = "Pharmacokinetics and safety of a phenytoin prodrug given IV or IM in patients",

abstract = "ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phosphatases. In this study, 43 patients received ACC-9653 IV or IM. Side effects were transient and minor. The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively. Peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration.",

author = "Leppik, {I. E.} and Boucher, {B. A.} and Wilder, {B. J.} and Murthy, {V. S.} and C. Watridge and Graves, {N. M.} and Rangel, {R. J.} and Rask, {C. A.} and P. Turlapaty",

year = "1990",

month = mar,

language = "English (US)",

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pages = "456--460",

journal = "Neurology",

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T1 - Pharmacokinetics and safety of a phenytoin prodrug given IV or IM in patients

AU - Leppik, I. E.

AU - Boucher, B. A.

AU - Wilder, B. J.

AU - Murthy, V. S.

AU - Watridge, C.

AU - Graves, N. M.

AU - Rangel, R. J.

AU - Rask, C. A.

AU - Turlapaty, P.

PY - 1990/3

Y1 - 1990/3

N2 - ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phosphatases. In this study, 43 patients received ACC-9653 IV or IM. Side effects were transient and minor. The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively. Peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration.

AB - ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phosphatases. In this study, 43 patients received ACC-9653 IV or IM. Side effects were transient and minor. The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively. Peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration.

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AN - SCOPUS:0025238997

VL - 40

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EP - 460

JO - Neurology

JF - Neurology

SN - 0028-3878

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ER -