Abstract
ACC-9653, a prodrug of phenytoin synthesized to be water soluble, is converted to phenytoin by phosphatases. In this study, 43 patients received ACC-9653 IV or IM. Side effects were transient and minor. The conversion half-lives of ACC-9653 after intravenous and intramuscular administration averaged 8.4 and 32.7 minutes, respectively. Peak phenytoin concentrations occurred 42 minutes after IV and 151 minutes after IM administration.
Original language | English (US) |
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Pages (from-to) | 456-460 |
Number of pages | 5 |
Journal | Neurology |
Volume | 40 |
Issue number | 3 |
State | Published - Mar 1990 |