Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats

Jibin Guan; Nana Zhao; Yinglei Zhai; Chunxia Chu; Hongming Chen; Tianhong Zhang

doi:10.1016/j.ajps.2014.07.004

Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats

Jibin Guan, Nana Zhao, Yinglei Zhai, Chunxia Chu, Hongming Chen, Tianhong Zhang

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats. The plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection (UPLC-MS/MS) through a new validated method. The pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows: AUC_0-t 900.76±186.59 versus 687.08±66.24ngh/ml, C_max 854.54±159.48 versus 610.59±235.99ng/ml, t_1/2 2.37±1.99 versus 2.80±2.69h. The relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4±11.3%. The developed methods could meet the requirements of bioanalysis. Compared to the solution injection, intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy.

Original language	English (US)
Pages (from-to)	330-335
Number of pages	6
Journal	Asian Journal of Pharmaceutical Sciences
Volume	9
Issue number	6
DOIs	https://doi.org/10.1016/j.ajps.2014.07.004
State	Published - Dec 1 2014
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2014 Shenyang Pharmaceutical University.

Keywords

Bioavailability
Method validation
Nitrendipine
Submicron emulsion

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10.1016/j.ajps.2014.07.004

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title = "Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats",

abstract = "To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats. The plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection (UPLC-MS/MS) through a new validated method. The pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows: AUC0-t 900.76±186.59 versus 687.08±66.24ngh/ml, Cmax 854.54±159.48 versus 610.59±235.99ng/ml, t1/2 2.37±1.99 versus 2.80±2.69h. The relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4±11.3%. The developed methods could meet the requirements of bioanalysis. Compared to the solution injection, intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy.",

keywords = "Bioavailability, Method validation, Nitrendipine, Submicron emulsion",

author = "Jibin Guan and Nana Zhao and Yinglei Zhai and Chunxia Chu and Hongming Chen and Tianhong Zhang",

note = "Publisher Copyright: {\textcopyright} 2014 Shenyang Pharmaceutical University.",

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doi = "10.1016/j.ajps.2014.07.004",

language = "English (US)",

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T1 - Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats

AU - Guan, Jibin

AU - Zhao, Nana

AU - Zhai, Yinglei

AU - Chu, Chunxia

AU - Chen, Hongming

AU - Zhang, Tianhong

PY - 2014/12/1

Y1 - 2014/12/1

N2 - To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats. The plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection (UPLC-MS/MS) through a new validated method. The pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows: AUC0-t 900.76±186.59 versus 687.08±66.24ngh/ml, Cmax 854.54±159.48 versus 610.59±235.99ng/ml, t1/2 2.37±1.99 versus 2.80±2.69h. The relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4±11.3%. The developed methods could meet the requirements of bioanalysis. Compared to the solution injection, intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy.

AB - To compare pharmacokinetic behaviors of nitrendipine submicron emulsion with nitrendipine solution following intravenous administration in rats. The plasma concentrations were analyzed by ultra-performance liquid chromatography coupled with tandem mass spectrometry detection (UPLC-MS/MS) through a new validated method. The pharmacokinetic parameters of the nitrendipine submicron emulsion and nitrendipine solution were as follows: AUC0-t 900.76±186.59 versus 687.08±66.24ngh/ml, Cmax 854.54±159.48 versus 610.59±235.99ng/ml, t1/2 2.37±1.99 versus 2.80±2.69h. The relative bioavailability of nitrendipine submicron emulsion to nitrendipine solution was 131.4±11.3%. The developed methods could meet the requirements of bioanalysis. Compared to the solution injection, intravenous submicron emulsion presents higher systematic exposure which can help to improve the therapeutic efficacy.

KW - Bioavailability

KW - Method validation

KW - Nitrendipine

KW - Submicron emulsion

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DO - 10.1016/j.ajps.2014.07.004

M3 - Article

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SN - 1818-0876

VL - 9

SP - 330

EP - 335

JO - Asian Journal of Pharmaceutical Sciences

JF - Asian Journal of Pharmaceutical Sciences

IS - 6

ER -

Pharmacokinetic performance of the nitrendipine intravenous submicron emulsion in rats

Abstract

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