Abstract
A 10-year-old boy with a history of heart transplantation had a potentially life-threatening decrease in his cyclosporine (CSA) blood levels during administration of bupropion. Subsequently he had an increase in CSA levels while receiving methylphenidate. These occurrences represent potential drug-drug interactions in children not previously documented in the literature. The CSA-bupropion and CSA-methylphenidate interactions merit further investigation, particularly because psychotropic agents are often prescribed in combination with immunosuppressants in transplantation patients of all ages.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 193-198 |
| Number of pages | 6 |
| Journal | Journal of child and adolescent psychopharmacology |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2001 |