Frank Pucino, Carol L. Beck, Randall L. Seifert, Gordon L. Strommen, Peggy A. Sheldon, Inger L. Silbergleit

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


The elderly comprise one of the fastest growing populations in the United States. By the year 2020, an estimated 45 million will be classified as elderly. Aging is a highly variable process as declines occur in physiologic functions. Alterations in cardiovascular, renal and hepatic function have the greatest effect on drug therapy. All pharmacokinetic and pharmacodynamic variables may be altered by age. Adverse drug reactions, drug interactions and poor compliance are frequent and may further complicate drug therapy. A review of those processes that commonly influence pharmacologic response and patient compliance to drug therapy is appropriate. 1985 Pharmacotherapy Publications Inc.

Original languageEnglish (US)
Pages (from-to)314-326
Number of pages13
JournalPharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Issue number6
StatePublished - 1985


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