Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit

Shuqin Zhou, Debra J. Skaar, Pamala A. Jacobson, R. Stephanie Huang

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU.

Original languageEnglish (US)
Article number1436
JournalFrontiers in Pharmacology
StatePublished - Dec 4 2018

Bibliographical note

Publisher Copyright:
© Copyright © 2018 Zhou, Skaar, Jacobson and Huang.


  • adverse drug reaction
  • intensive care unit
  • personalized medicine
  • pharmacogenetics
  • pharmacogenomics


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