Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit

Shuqin Zhou; Debra J. Skaar; Pamala A. Jacobson; R. Stephanie Huang

doi:10.3389/fphar.2018.01436

Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit

Shuqin Zhou, Debra J. Skaar, Pamala A. Jacobson, R. Stephanie Huang

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU.

Original language	English (US)
Article number	1436
Journal	Frontiers in Pharmacology
Volume	9
DOIs	https://doi.org/10.3389/fphar.2018.01436
State	Published - Dec 4 2018

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Publisher Copyright:
© Copyright © 2018 Zhou, Skaar, Jacobson and Huang.

Keywords

adverse drug reaction
intensive care unit
personalized medicine
pharmacogenetics
pharmacogenomics

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10.3389/fphar.2018.01436

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abstract = "In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU.",

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AU - Huang, R. Stephanie

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N2 - In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU.

AB - In the intensive care unit (ICU) setting, where highly variable and insufficient drug efficacies, as well as frequent and unpredictable adverse drug reactions (ADRs) occur, pharmacogenomics (PGx) offers an opportunity to improve health outcomes. However, PGx has not been fully evaluated in the ICU, partly due to lack of knowledge of how genetic markers may affect drug therapy. To fill in this gap, we conducted a review to summarize the PGx information for the medications commonly encountered in the ICU.

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KW - personalized medicine

KW - pharmacogenetics

KW - pharmacogenomics

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Pharmacogenomics of Medications Commonly Used in the Intensive Care Unit

Abstract

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