Pharmacogenomics of heart failure: a systematic review

Fannie Mottet, Orly Vardeny, Simon De Denus

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Background: Heart failure (HF) and multiple HF-related phenotypes are heritable. Genes implicated in the HF pathophysiology would be expected to influence the response to treatment. Methods: We conducted a series of systematic literature searches on the pharmacogenetics of HF therapy to assess the current knowledge on this field. Results: Existing data related to HF pharmacogenomics are still limited. The ADRB1 gene is a likely candidate to predict response to β-blockers. Moreover, the cytochrome P450 2D6 coding gene (CYP2D6) clearly affects the pharmacokinetics of metoprolol, although the clinical impact of this association remains to be established. Conclusion: Given the rising prevalence of HF and related costs, a more personalized use of HF drugs could have a remarkable benefit for patients, caregivers and healthcare systems.

Original languageEnglish (US)
Pages (from-to)1817-1858
Number of pages42
Issue number16
StatePublished - Nov 2016

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© 2016 Future Medicine Ltd.


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