Pharmacogenomics of cisplatin sensitivity in non-small cell lung cancer

Maimon C. Rose, Elina Kostyanovskaya, R. Stephanie Huang

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Cisplatin, a platinum-based chemotherapeutic drug, has been used for over 30. years in a wide variety of cancers with varying degrees of success. In particular, cisplatin has been used to treat late stage non-small cell lung cancer (NSCLC) as the standard of care. However, therapeutic outcomes vary from patient to patient. Considerable efforts have been invested to identify biomarkers that can be used to predict cisplatin sensitivity in NSCLC. Here we reviewed current evidence for cisplatin sensitivity biomarkers in NSCLC. We focused on several key pathways, including nucleotide excision repair, drug transport and metabolism. Both expression and germline DNA variation were evaluated in these key pathways. Current evidence suggests that cisplatin-based treatment could be improved by the use of these biomarkers.

Original languageEnglish (US)
Pages (from-to)198-209
Number of pages12
JournalGenomics, Proteomics and Bioinformatics
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2014

Bibliographical note

Funding Information:
RSH receives support from the NIH/NIGMS (Grant Nos. U01GM61393 and K08GM089941), NIH/NCI (Grant No. R21 CA139278), University of Chicago Cancer Center Support Grant (Grant No. P30 CA14599), Breast Cancer SPORE Career Development Award (Grant No. CA125183) and the National Center for Advancing Translational Sciences of the NIH (Grant No. UL1RR024999) of the United States.

Keywords

  • Biomarker
  • Cisplatin
  • Copper transport
  • Glutathione S-transferase
  • Non-small cell lung cancer
  • Nucleotide excision repair

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