Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction

Jeffrey R. Bishop, Sharon S. Chae, Shitalben Patel, Jessica Moline, Vicki L. Ellingrod

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. One polymorphism in GRIA1 (rs1994862) was associated with arousal dysfunction, providing further evidence for the role of GRIA1 in mechanisms underlying SSRI-associated sexual side effects.

Original languageEnglish (US)
Pages (from-to)74-76
Number of pages3
JournalPsychiatry Research
Issue number1
StatePublished - Aug 30 2012


  • Antidepressant
  • Sexual dysfunction
  • Single-nucleotide polymorphism


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