Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction

Jeffrey R. Bishop; Sharon S. Chae; Shitalben Patel; Jessica Moline; Vicki L. Ellingrod

doi:10.1016/j.psychres.2012.03.048

Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction

Jeffrey R. Bishop, Sharon S. Chae, Shitalben Patel, Jessica Moline, Vicki L. Ellingrod

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. One polymorphism in GRIA1 (rs1994862) was associated with arousal dysfunction, providing further evidence for the role of GRIA1 in mechanisms underlying SSRI-associated sexual side effects.

Original language	English (US)
Pages (from-to)	74-76
Number of pages	3
Journal	Psychiatry Research
Volume	199
Issue number	1
DOIs	https://doi.org/10.1016/j.psychres.2012.03.048
State	Published - Aug 30 2012

Keywords

Antidepressant
Sexual dysfunction
Single-nucleotide polymorphism

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10.1016/j.psychres.2012.03.048

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AU - Chae, Sharon S.

AU - Patel, Shitalben

AU - Moline, Jessica

AU - Ellingrod, Vicki L.

PY - 2012/8/30

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AB - We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. One polymorphism in GRIA1 (rs1994862) was associated with arousal dysfunction, providing further evidence for the role of GRIA1 in mechanisms underlying SSRI-associated sexual side effects.

KW - Antidepressant

KW - Sexual dysfunction

KW - Single-nucleotide polymorphism

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JO - Psychiatry Research

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ER -

Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction

Abstract

Keywords

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