Pharmacogenetics

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Pharmacogenetics is the study of how genetics influences drug treatment outcomes. Much research has been conducted to identify and characterize gene variants that impact the pharmacokinetic and pharmacodynamic aspects of medications used to treat neurologic and psychiatric disorders. This chapter reviews the current state of pharmacogenetic aspects of these treatments. Medications with supporting pharmacogenetic information in product labeling, clinical guidelines, or important mechanistic implications are discussed. At this time, clinically relevant genetic variation in drug metabolizing enzymes may inform drug dosing for a number of medications metabolized in the liver. Additionally, genetic variation in immunological genes may be tested to assess risk for severe hypersensitivity reactions to some anticonvulsant drugs. Finally, a growing body of research highlights that genetic polymorphisms in drug targets may influence symptom response or tolerability to some treatments.

Original languageEnglish (US)
Title of host publicationHandbook of Clinical Neurology
PublisherElsevier B.V.
Pages59-73
Number of pages15
DOIs
StatePublished - Jan 1 2018

Publication series

NameHandbook of Clinical Neurology
Volume147
ISSN (Print)0072-9752
ISSN (Electronic)2212-4152

Keywords

  • anticonvulsant
  • antidepressant
  • antipsychotic
  • anxiolytic
  • mood stabilizer
  • pharmacogenetics
  • pharmacogenomics

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