Pharmaceutical powders flow properties characterization: methods and applications

Chen Guang Wang, Jian Guo Fang

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Various methods are used for measuring flow properties of pharmaceutical powders, such as angle of repose, flow through an orifice, compressibility index, hausner ratio, shear cell, etc. Among these methods, shear cell test provides quantitative and reproducible results. Some pharmaceutical applications of ring shear cell were introduced, including quantifying the effects of particulate properties on powder flow properties; setting the bar for powder flow properties in successful high speed tableting; and profoundly improving flow properties of a cohesive powder by nanocoating.

Original languageEnglish (US)
Pages (from-to)809-813
Number of pages5
JournalChinese Journal of New Drugs
Volume22
Issue number7
StatePublished - Apr 15 2013
Externally publishedYes

Keywords

  • High speed tablet manufacturing
  • Microcrystalline cellulose
  • Nanocoating
  • Powder flow properties
  • Quality by design
  • Shear cell method

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