Phagocytosis of candida albicans by RNAi-treated drosophila S2 cells

Shannon L. Stroschein-Stevenson, Edan Foley, Patrick H. O'Farrell, Alexander D. Johnson

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations


Phagocytosis is a highly conserved aspect of innate immunity. Drosophila melanogaster has an innate immune system with many similarities to that of mammals and has been used to successfully model many aspects of innate immunity. The recent availability of Ribo Nucleic Acid interference (RNAi) libraries for Drosophila has made it possible to efficiently screen for genes important in aspects of innate immunity. We have screened an RNAi library representing 7216 fly genes conserved among metazoans to identify proteins required for the phagocytosis of the human fungal pathogen Candida albicans.

Original languageEnglish (US)
Title of host publicationHost-Pathogen Interactions
Subtitle of host publicationMethods and Protocols
PublisherHumana Press
Number of pages12
ISBN (Print)9781588298867
StatePublished - Feb 6 2009

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Candida albicans
  • Cell culture
  • Double-stranded RNA
  • Drosophila
  • Immunofluorescence
  • Phagocytosis
  • RNAi
  • S2 cells


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