PH-responsive micelles based on amphiphilic block copolymers bearing ortho ester pendants as potential drug carriers

Rupei Tang, Weihang Ji, Chun Wang

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Amphiphilic block copolymers (PEG-b-PEYM) bearing acid-labile ortho ester pendant chains were synthesized by atom transfer radical polymerization, and the effect of chain-length of the ortho-ester-bearing PEYM block on micelle properties was investigated. The length of the PEYM block affected the critical micelle concentration and pH-dependent average particle size but not the kinetics of side-chain hydrolysis. A hydrophobic dye, Nile red, was loaded in the micelles. Both the loading content and the size of the loaded micelles were influenced by the length of the PEYM block, whereas the release kinetics of Nile red was not. Provided that these acid-labile micelles are completely cell compatible, they are potentially useful bioresponsive nanocarriers for enhancing the efficacy of hydrophobic drugs.

Original languageEnglish (US)
Pages (from-to)1185-1192
Number of pages8
JournalMacromolecular Chemistry and Physics
Volume212
Issue number11
DOIs
StatePublished - Jun 1 2011

Keywords

  • block copolymers
  • drug delivery systems
  • micelles
  • nanoparticles
  • stimuli-sensitive polymers

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