The new aspect of our work is to reveal that Ph-like alterations are common among patients with Ph-ALL experiencing relapse after hematopoietic cell transplantation (HCT), despite acquisition of MRD-negative complete responses prior to transplant. This is also the central finding of our work. Therefore, the anticipated benefits of HCT appear diminished among this patient subset; such patients may be better served with efforts to further increase MRD depth prior to HCT, or alternative therapies.
Bibliographical noteFunding Information:
This publication was made possible by an NIEHS‐funded predoctoral fellowship to S.T (T32HL007062).
- Chromosome Aberrations
- Hematopoietic Stem Cell Transplantation/adverse effects
- Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis
- Retrospective Studies
- Transplantation, Homologous
PubMed: MeSH publication types