Ph-like gene alterations and complex chromosomal abnormalities are frequent in patients with acute lymphoblastic leukemia experiencing relapse after allogeneic hematopoietic cell transplantation

Sean I. Tracy; Qing Cao; Ben Bachan; Matthew Meredith; Le Ann Oseth; Daniel Weisdorf; Claudio Brunstein; Betsy Hirsch; Veronika Bachanova

doi:10.1111/ejh.13814

Ph-like gene alterations and complex chromosomal abnormalities are frequent in patients with acute lymphoblastic leukemia experiencing relapse after allogeneic hematopoietic cell transplantation

Sean I. Tracy, Qing Cao, Ben Bachan, Matthew Meredith, Le Ann Oseth, Daniel Weisdorf, Claudio Brunstein, Betsy Hirsch, Veronika Bachanova

Research output: Contribution to journal › Letter › peer-review

1 Scopus citations

Abstract

The new aspect of our work is to reveal that Ph-like alterations are common among patients with Ph-ALL experiencing relapse after hematopoietic cell transplantation (HCT), despite acquisition of MRD-negative complete responses prior to transplant. This is also the central finding of our work. Therefore, the anticipated benefits of HCT appear diminished among this patient subset; such patients may be better served with efforts to further increase MRD depth prior to HCT, or alternative therapies.

Original language	English (US)
Journal	European Journal of Haematology
Volume	109
Issue number	4
DOIs	https://doi.org/10.1111/ejh.13814
State	Published - Oct 2022

Bibliographical note

Funding Information:
This publication was made possible by an NIEHS‐funded predoctoral fellowship to S.T (T32HL007062).

Keywords

Chromosome Aberrations
Hematopoietic Stem Cell Transplantation/adverse effects
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis
Recurrence
Retrospective Studies
Transplantation, Homologous

PubMed: MeSH publication types

Letter

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10.1111/ejh.13814

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Tracy, S. I., Cao, Q., Bachan, B., Meredith, M., Oseth, L. A., Weisdorf, D., Brunstein, C., Hirsch, B., & Bachanova, V. (2022). Ph-like gene alterations and complex chromosomal abnormalities are frequent in patients with acute lymphoblastic leukemia experiencing relapse after allogeneic hematopoietic cell transplantation. European Journal of Haematology, 109(4). https://doi.org/10.1111/ejh.13814

Ph-like gene alterations and complex chromosomal abnormalities are frequent in patients with acute lymphoblastic leukemia experiencing relapse after allogeneic hematopoietic cell transplantation. / Tracy, Sean I.; Cao, Qing; Bachan, Ben et al.
In: European Journal of Haematology, Vol. 109, No. 4, 10.2022.

Research output: Contribution to journal › Letter › peer-review

Tracy, SI , Cao, Q, Bachan, B, Meredith, M, Oseth, LA, Weisdorf, D, Brunstein, C, Hirsch, B & Bachanova, V 2022, 'Ph-like gene alterations and complex chromosomal abnormalities are frequent in patients with acute lymphoblastic leukemia experiencing relapse after allogeneic hematopoietic cell transplantation', European Journal of Haematology, vol. 109, no. 4. https://doi.org/10.1111/ejh.13814

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abstract = "The new aspect of our work is to reveal that Ph-like alterations are common among patients with Ph-ALL experiencing relapse after hematopoietic cell transplantation (HCT), despite acquisition of MRD-negative complete responses prior to transplant. This is also the central finding of our work. Therefore, the anticipated benefits of HCT appear diminished among this patient subset; such patients may be better served with efforts to further increase MRD depth prior to HCT, or alternative therapies.",

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AU - Bachan, Ben

AU - Meredith, Matthew

AU - Oseth, Le Ann

AU - Weisdorf, Daniel

AU - Brunstein, Claudio

AU - Hirsch, Betsy

AU - Bachanova, Veronika

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KW - Hematopoietic Stem Cell Transplantation/adverse effects

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KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis

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Ph-like gene alterations and complex chromosomal abnormalities are frequent in patients with acute lymphoblastic leukemia experiencing relapse after allogeneic hematopoietic cell transplantation

Abstract

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Keywords

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