pH-hysteresis of glucose permeability in acid-doped LCST hydrogels - a basis for pulsatile, oscillatory drug release

X. Zou; J. C. Leroux; J. P. Baker; R. A. Siegel

pH-hysteresis of glucose permeability in acid-doped LCST hydrogels - a basis for pulsatile, oscillatory drug release

X. Zou
, J. C. Leroux
, J. P. Baker
, R. A. Siegel

Pharmaceutics

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

A scheme for a pulsatile drug delivery oscillator is proposed. A simple model identifies device characteristics that are needed to achieve such behavior. In particular, the permeability of the membrane to substrate (glucose) needs to show hysteresis with respect to product (H⁺) concentration. It is also shown that the membranes with this property can be constructed. The response of these membranes depends to some degree on the presence or absence of pH buffers, and this phenomenon impinges on the parameter specifications to be used in this theory.

Original language	English (US)
Pages (from-to)	444-445
Number of pages	2
Journal	Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
Volume	76
State	Published - Jan 1 1997
Event	Proceedings of the 1997 Spring ACS Meeting - San Francisco, CA, USA Duration: Apr 13 1997 → Apr 17 1997

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pH-hysteresis of glucose permeability in acid-doped LCST hydrogels - a basis for pulsatile, oscillatory drug release. / Zou, X.; Leroux, J. C.; Baker, J. P. et al.
In: Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, Vol. 76, 01.01.1997, p. 444-445.

Research output: Contribution to journal › Conference article › peer-review

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abstract = "A scheme for a pulsatile drug delivery oscillator is proposed. A simple model identifies device characteristics that are needed to achieve such behavior. In particular, the permeability of the membrane to substrate (glucose) needs to show hysteresis with respect to product (H+) concentration. It is also shown that the membranes with this property can be constructed. The response of these membranes depends to some degree on the presence or absence of pH buffers, and this phenomenon impinges on the parameter specifications to be used in this theory.",

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AU - Siegel, R. A.

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N2 - A scheme for a pulsatile drug delivery oscillator is proposed. A simple model identifies device characteristics that are needed to achieve such behavior. In particular, the permeability of the membrane to substrate (glucose) needs to show hysteresis with respect to product (H+) concentration. It is also shown that the membranes with this property can be constructed. The response of these membranes depends to some degree on the presence or absence of pH buffers, and this phenomenon impinges on the parameter specifications to be used in this theory.

AB - A scheme for a pulsatile drug delivery oscillator is proposed. A simple model identifies device characteristics that are needed to achieve such behavior. In particular, the permeability of the membrane to substrate (glucose) needs to show hysteresis with respect to product (H+) concentration. It is also shown that the membranes with this property can be constructed. The response of these membranes depends to some degree on the presence or absence of pH buffers, and this phenomenon impinges on the parameter specifications to be used in this theory.

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M3 - Conference article

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JO - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering

JF - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering

T2 - Proceedings of the 1997 Spring ACS Meeting

Y2 - 13 April 1997 through 17 April 1997

ER -

pH-hysteresis of glucose permeability in acid-doped LCST hydrogels - a basis for pulsatile, oscillatory drug release

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