A scheme for a pulsatile drug delivery oscillator is proposed. A simple model identifies device characteristics that are needed to achieve such behavior. In particular, the permeability of the membrane to substrate (glucose) needs to show hysteresis with respect to product (H+) concentration. It is also shown that the membranes with this property can be constructed. The response of these membranes depends to some degree on the presence or absence of pH buffers, and this phenomenon impinges on the parameter specifications to be used in this theory.
|Original language||English (US)|
|Number of pages||2|
|Journal||Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering|
|State||Published - Jan 1 1997|
|Event||Proceedings of the 1997 Spring ACS Meeting - San Francisco, CA, USA|
Duration: Apr 13 1997 → Apr 17 1997