pH-hysteresis of glucose permeability in acid-doped LCST hydrogels - a basis for pulsatile, oscillatory drug release

X. Zou, J. C. Leroux, J. P. Baker, R. A. Siegel

Research output: Contribution to journalConference article

1 Scopus citations

Abstract

A scheme for a pulsatile drug delivery oscillator is proposed. A simple model identifies device characteristics that are needed to achieve such behavior. In particular, the permeability of the membrane to substrate (glucose) needs to show hysteresis with respect to product (H+) concentration. It is also shown that the membranes with this property can be constructed. The response of these membranes depends to some degree on the presence or absence of pH buffers, and this phenomenon impinges on the parameter specifications to be used in this theory.

Original languageEnglish (US)
Pages (from-to)444-445
Number of pages2
JournalPolymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
Volume76
StatePublished - Jan 1 1997
EventProceedings of the 1997 Spring ACS Meeting - San Francisco, CA, USA
Duration: Apr 13 1997Apr 17 1997

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