TY - JOUR
T1 - pH-hysteresis of glucose permeability in acid-doped LCST hydrogels - a basis for pulsatile, oscillatory drug release
AU - Zou, X.
AU - Leroux, J. C.
AU - Baker, J. P.
AU - Siegel, R. A.
PY - 1997/1/1
Y1 - 1997/1/1
N2 - A scheme for a pulsatile drug delivery oscillator is proposed. A simple model identifies device characteristics that are needed to achieve such behavior. In particular, the permeability of the membrane to substrate (glucose) needs to show hysteresis with respect to product (H+) concentration. It is also shown that the membranes with this property can be constructed. The response of these membranes depends to some degree on the presence or absence of pH buffers, and this phenomenon impinges on the parameter specifications to be used in this theory.
AB - A scheme for a pulsatile drug delivery oscillator is proposed. A simple model identifies device characteristics that are needed to achieve such behavior. In particular, the permeability of the membrane to substrate (glucose) needs to show hysteresis with respect to product (H+) concentration. It is also shown that the membranes with this property can be constructed. The response of these membranes depends to some degree on the presence or absence of pH buffers, and this phenomenon impinges on the parameter specifications to be used in this theory.
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M3 - Conference article
AN - SCOPUS:0030714207
SN - 0743-0515
VL - 76
SP - 444
EP - 445
JO - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
JF - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
T2 - Proceedings of the 1997 Spring ACS Meeting
Y2 - 13 April 1997 through 17 April 1997
ER -