pH-Controlled release from hydrophobic/polyelectrolyte copolymer hydrogels

Ronald A. Siegel, Mahmood Falamarzian, Bruce A. Firestone, Bret C. Moxley

Research output: Contribution to journalArticle

239 Scopus citations

Abstract

Hydrophobic polyamine copolymer hydrogels, loaded with caffeine, release the drug at rates that vary sharply with pH. At neutral pH virtually no caffeine is released, while at pH 3 and 5 the drug is released with near-zero order kinetics, the release rate being greater at pH 3. Water sorption was measured concurrently, and the release of caffeine closely follows water uptake at pH 3 and 5, providing strong evidence for a moving front mechanism for sorption and release.

Original languageEnglish (US)
Pages (from-to)179-182
Number of pages4
JournalJournal of Controlled Release
Volume8
Issue number2
DOIs
StatePublished - Dec 1988

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