pH-Controlled release from hydrophobic/polyelectrolyte copolymer hydrogels

Ronald A. Siegel, Mahmood Falamarzian, Bruce A. Firestone, Bret C. Moxley

Research output: Contribution to journalArticlepeer-review

253 Scopus citations


Hydrophobic polyamine copolymer hydrogels, loaded with caffeine, release the drug at rates that vary sharply with pH. At neutral pH virtually no caffeine is released, while at pH 3 and 5 the drug is released with near-zero order kinetics, the release rate being greater at pH 3. Water sorption was measured concurrently, and the release of caffeine closely follows water uptake at pH 3 and 5, providing strong evidence for a moving front mechanism for sorption and release.

Original languageEnglish (US)
Pages (from-to)179-182
Number of pages4
JournalJournal of Controlled Release
Issue number2
StatePublished - Dec 1988

Bibliographical note

Funding Information:
This work was funded by grants from NIH (DK 38035) and the Diabetes Research and Education Foundation.


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