PGC-1α overexpression partially rescues impaired oxidative and contractile pathophysiology following volumetric muscle loss injury

William M. Southern, Anna S. Nichenko, Kayvan F. Tehrani, Melissa J. McGranahan, Laxminarayanan Krishnan, Anita E. Qualls, Nathan T. Jenkins, Luke J. Mortensen, Hang Yin, Amelia Yin, Robert E. Guldberg, Sarah M. Greising, Jarrod A. Call

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Volumetric muscle loss (VML) injury is characterized by a non-recoverable loss of muscle fibers due to ablative surgery or severe orthopaedic trauma, that results in chronic functional impairments of the soft tissue. Currently, the effects of VML on the oxidative capacity and adaptability of the remaining injured muscle are unclear. A better understanding of this pathophysiology could significantly shape how VML-injured patients and clinicians approach regenerative medicine and rehabilitation following injury. Herein, the data indicated that VML-injured muscle has diminished mitochondrial content and function (i.e., oxidative capacity), loss of mitochondrial network organization, and attenuated oxidative adaptations to exercise. However, forced PGC-1α over-expression rescued the deficits in oxidative capacity and muscle strength. This implicates physiological activation of PGC1-α as a limiting factor in VML-injured muscle’s adaptive capacity to exercise and provides a mechanistic target for regenerative rehabilitation approaches to address the skeletal muscle dysfunction.

Original languageEnglish (US)
Article number4079
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

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