PFK-2/FBPase-2: Maker and breaker of the essential biofactor fructose-2,6-bisphosphate

David A. Okar, Alex J Lange, Ànna Manzano, Aurèa Navarro-Sabatè, Llus Riera, Ramon Bartrons

Research output: Contribution to journalReview articlepeer-review

293 Scopus citations


Fructose-2,6-bisphosphate is responsible for mediating glucagon-stimulated gluconeogenesis in the liver. This discovery has led to the realization that this compound plays a significant role in directing carbohydrate fluxes in all eukaryotes. Biophysical studies of the enzyme that both synthesizes and degrades this biofactor have yielded insight into its molecular enzymology. Moreover, the metabolic role of fructose-2,6-bisphosphate has great potential in the treatment of diabetes.

Original languageEnglish (US)
Pages (from-to)30-35
Number of pages6
JournalTrends in Biochemical Sciences
Issue number1
StatePublished - Jan 1 2001


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