Pervasive Charge Solvation Permeates Native-like Protein Ions and Dramatically Influences Top-down Sequencing Data

Keyphrases

• Sequence Data 100%
• Native-like 100%
• Protein Ions 100%
• Mobile Proton Model 100%
• Charge Solvation 100%
• Top-down Sequencing 100%
• Protein Complex 66%
• Lysine Residue 66%
• Protein Sequence 66%
• Intact Protein 66%
• Positive Charge 66%
• Proteoform 66%
• Proteomics 33%
• Gas Phase 33%
• Molecular Dynamics Simulation 33%
• Post-translational Modification 33%
• Positively Charged 33%
• Side Chain 33%
• Helix 33%
• Dipole 33%
• Solvate 33%
• Fixed Charge 33%
• Physical Forces 33%
• Fragmentation Pathway 33%
• Mobile Charge 33%
• Pyrylium 33%
• Precursor Ions 33%
• Carbodiimide Chemistry 33%
• Solvation Process 33%
• Top-down Protein Sequencing 33%
• Charge-remote 33%
• Charge-remote Fragmentation 33%
• Slow Heating 33%

Chemistry

• Solvation 100%
• Lysine 100%
• Amino Acid Sequence 100%
• permeates 100%
• Chemistry 50%
• Carbodiimide 50%
• Pyrylium 50%
• formation 50%
• solvate 50%
• Proteomics 50%
• Post-Translational Modification 50%
• Protein Sequencing 50%
• Molecular Dynamics Simulation 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Lysine 100%
• Protein Sequencing 50%
• Cyanamide 50%
• Multiprotein Complex 50%
• Diseases 50%