Abstract
Lymphocytic choriomeningitis virus (LCMV) Armstrong caused disordered growth and glucose metabolism secondary to growth hormone deficiency in infected C3H/St mice. In contrast, LCMV strain WE replicated in fewer growth hormone-producing cells, failed to disrupt growth hormone synthesis, and did not cause growth hormone-induced disease in infected, matched controls. The generation of genetic reassortant viruses between the virulent strain of LCMV:Armstrong and the avirulent strain, LCMV:WE, is reported. Using such reassortants and both parental strains of virus in C3H/St mice, the perturbation of growth hormone synthesis was clearly mapped to the S RNA segment of LCMV:ARM.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 175-182 |
| Number of pages | 8 |
| Journal | Virology |
| Volume | 142 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 15 1985 |
Bibliographical note
Funding Information:This is Publication 3545-IMM from the Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037 . This work was supported in part by Grants AI-09484, AG-04342, and NS-12428 from the U. S. Public Health Service. Y .R. is the recipient of Fogarty international research fellowship No. 1 P05 TWO3304 from the U . S. Public Health Service, and funds from the Fondation de l'industrie pharmaceutique pour Is recherche and the Philippe Foundation. The authors thank Michael Buchmeier for critical review and Gay Wilkins and Sally Boos for manuscript preparation .