Persufflation (gaseous oxygen perfusion) as a method of heart preservation

Thomas M. Suszynski; Michael D. Rizzari; William E. Scott; Peter M. Eckman; James D. Fonger; Ranjit John; Nicolas Chronos; Linda A. Tempelman; David E.R. Sutherland; Klearchos K. Papas

doi:10.1186/1749-8090-8-105

Persufflation (gaseous oxygen perfusion) as a method of heart preservation

Thomas M. Suszynski, Michael D. Rizzari, William E. Scott, Peter M. Eckman, James D. Fonger, Ranjit John, Nicolas Chronos, Linda A. Tempelman, David E.R. Sutherland, Klearchos K. Papas

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggests that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.

Original language	English (US)
Article number	105
Journal	Journal of Cardiothoracic Surgery
Volume	8
Issue number	1
DOIs	https://doi.org/10.1186/1749-8090-8-105
State	Published - Apr 22 2013

Bibliographical note

Funding Information:
We would like to acknowledge financial support from NIH/NIDDK grant R44 DK070400.

Keywords

Heart transplantation
Ischemia
Organ preservation
Perfusion

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10.1186/1749-8090-8-105

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abstract = "Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggests that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.",

keywords = "Heart transplantation, Ischemia, Organ preservation, Perfusion",

author = "Suszynski, {Thomas M.} and Rizzari, {Michael D.} and Scott, {William E.} and Eckman, {Peter M.} and Fonger, {James D.} and Ranjit John and Nicolas Chronos and Tempelman, {Linda A.} and Sutherland, {David E.R.} and Papas, {Klearchos K.}",

note = "Funding Information: We would like to acknowledge financial support from NIH/NIDDK grant R44 DK070400.",

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doi = "10.1186/1749-8090-8-105",

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AU - Suszynski, Thomas M.

AU - Rizzari, Michael D.

AU - Scott, William E.

AU - Eckman, Peter M.

AU - Fonger, James D.

AU - John, Ranjit

AU - Chronos, Nicolas

AU - Tempelman, Linda A.

AU - Sutherland, David E.R.

AU - Papas, Klearchos K.

N1 - Funding Information: We would like to acknowledge financial support from NIH/NIDDK grant R44 DK070400.

PY - 2013/4/22

Y1 - 2013/4/22

N2 - Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggests that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.

AB - Persufflation (PSF; gaseous oxygen perfusion) is an organ preservation technique with a potential for use in donor heart preservation. Improved heart preservation with PSF may improve outcomes by maintaining cardiac tissue quality in the setting of longer cold ischemia times and possibly increasing the number of donor hearts available for allotransplant. Published data suggests that PSF is able to extend the cold storage times for porcine hearts up to 14 hours without compromising viability and function, and has been shown to resuscitate porcine hearts following donation after cardiac death. This review summarizes key published work on heart PSF, including prospective implications and future directions for PSF in heart transplantation. We emphasize the potential impact of extending preservation times and expanding donor selection criteria in heart allotransplant. Additionally, the key issues that need to be addressed before PSF were to become a widely utilized preservation strategy prior to clinical heart transplantation are summarized and discussed.

KW - Heart transplantation

KW - Ischemia

KW - Organ preservation

KW - Perfusion

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Persufflation (gaseous oxygen perfusion) as a method of heart preservation

Abstract

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