Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

S. Venkatesan, R. Rosenthal, N. Kanu, N. McGranahan, J. Bartek, S. A. Quezada, J. Hare, R. S. Harris, C. Swanton

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) mutational signature has only recently been detected in a multitude of cancers through next-generation sequencing. In contrast, APOBEC has been a focus of virology research for over a decade. Many lessons learnt regarding APOBEC within virology are likely to be applicable to cancer. In this review, we explore the parallels between the role of APOBEC enzymes in HIV and cancer evolution. We discuss data supporting the role of APOBEC mutagenesis in creating HIV genome heterogeneity, drug resistance, and immune escape variants. We hypothesize similar functions of APOBEC will also hold true in cancer.

Original languageEnglish (US)
Pages (from-to)563-572
Number of pages10
JournalAnnals of Oncology
Volume29
Issue number3
DOIs
StatePublished - Mar 1 2018

Keywords

  • APOBEC
  • Drug resistance
  • Human immunodeficiency virus
  • Immune escape
  • Intratumour heterogeneity

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