Personalized circadian timing of exercise

R. B. Singh, Franz Halberg, Germaine Cornelissen, Jarmila Siegelova, Krasimira Hristova, Eri Toda, Toru Takahashi, Jan Fedacko, Kuniaki Otsuka

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20 Scopus citations


That exercise effects are circadian stage dependent and that exercise at the wrong circadian stages can induce a Vascular Variability Disorder (VVD) has been documented earlier. Herein we show how statistically significant results can be obtained with a simple individualized design, that can be self-applied by everybody to optimize a desired effect by Chronobiologically-interpreted Ambulatory Blood Pressure (BP) and heart rate (HR) Monitoring C-ABPM). A 68-year old internist cardiologist monitored himself at halfhourly intervals, with interruptions, for 3-to7-day sessions, exercise timing being kept the same within a given session and changed from one session to another. Exercise training in the morning was associated with lowest BP and HR MESORs (Midline Estimating Statistic Of Rhythm, a rhythm-adjusted mean) as compared to exercise done at mid-day, late afternoon or in the evening. We review some of the literature, speculate about its meaning, yet do not stray beyond a single case in our conclusions for everybody: it seems possible and desirable to personalize exercise at a time of pertinence rather than convenience. One shoe or one timing does not fit all.

Original languageEnglish (US)
Pages (from-to)79-90
Number of pages12
JournalWorld Heart Journal
Issue number2
StatePublished - Dec 1 2013


  • Blood pressure
  • Circadian
  • Heart rate
  • Physical activity
  • Timing

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    Singh, R. B., Halberg, F., Cornelissen, G., Siegelova, J., Hristova, K., Toda, E., Takahashi, T., Fedacko, J., & Otsuka, K. (2013). Personalized circadian timing of exercise. World Heart Journal, 5(2), 79-90.